Southeastern Greyhound Lines operated many routes in addition to the ones mentioned in part one from the Lexington, KY bus station located at Short and Sycamore in Downtown Lexington.

The primary north to south routes operated via I -75 and US 25 to Cincinnati and Knoxville stops included Richmond, Berea,Renfro Valley, Mt. Vernon, Livingston, London, Corbin, Barbourville,Pineville, Middlesboro,in Kentucky and Haragate, Tazewell, Maynardville, and also via Williamsburg and Jellico on certian runs, towards Cincinnati the bus stopped at Williamstown, Georgetown and Covington

Other Lexington routes included Lexington - Somerset - Chattanooga with stops in  Harrodsburg, Danville, Stanford, Somerset, Whitley City in Kentucky and Oneida, Wartburg, Hariman, Rockwood, Spring City and Dayton in Tennessee

Another route operated via Paris to Cincinnati and Maysville, Greyhound offered a commuter schedule between Mt Sterling and Lexington.

In nearby Frankfort Trailways offered service between Cincinnati and Knoxville stopping's at Dry Ridge, Holbrook,Needmore,Sweet Owen,Owenton, Monterey, Frankfort, Alton, Lawernceburg,Harrodsburg,Danville, Stanford,Brodhead, Crab Orchard, Mt Vernon, Lilly, Corbin, Williamsburg in Kentucky and Jellico, Caryville, Lake City, Clinton and Knoxville in Tennessee